Article

DNMT1 can induce primary germ layer differentiation through de novo DNA methylation

2023-05-08

Abstract excerpt

<title>Abstract</title> <p>DNA methyltransferases and TET enzymes dynamically regulate the DNA methylation-demethylation cycles during mouse embryonic development. DNMT1 maintains cell-specific DNA methylation after DNA replication. However, little is known about the physiological significance of the de novo methylation enzymatic potential of DNMT1, which has attracted much attention. Here, we show that the full-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cad4db30-f206-5670-8250-7ea8984eec13
DOI: 10.21203/rs.3.rs-2788282/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNMT1 can induce primary germ layer differentiation through de novo DNA methylationDOI 10.21203/rs.3.rs-2788282/v1Read

DNMT1 can induce primary germ layer differentiation through de novo DNA methylationSemantic proximity Read

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read

DNMT1 overexpression disrupts DNA methylation homeostasis in mouse embryonic stem cellsSemantic proximity Read

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammalsSemantic proximity Read

Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylationSemantic proximity Read

Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryosSemantic proximity Read

Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3ASemantic proximity Read

Developmental Genome-Wide DNA Methylation Asymmetry Between Mouse Placenta and EmbryoSemantic proximity Read

Preventing CpG island hypermethylation in oocytes safeguards mouse developmentSemantic proximity Read

Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissuesSemantic proximity Read

Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3BSemantic proximity Read