Article
Spatiotemporal DNA methylome dynamics of the developing mouse fetus.
Nature - 1 Jul 2020
He Yupeng, Hariharan Manoj, Gorkin David U, Dickel Diane E, Luo Chongyuan, Castanon Rosa G, Nery Joseph R, Lee Ah Young, Zhao Yuan, Huang Hui, Williams Brian A, Trout Diane, Amrhein Henry, Fang Rongxin, Chen Huaming, Li Bin, Visel Axel, Pennacchio Len A, Ren Bing, Ecker Joseph R
Abstract excerpt
Cytosine DNA methylation is essential for mammalian development but understanding of its spatiotemporal distribution in the developing embryo remains limited1,2. Here, as part of the mouse Encyclopedia of DNA Elements (ENCODE) project, we profiled 168 methylomes from 12 mouse tissues or organs at 9 developmental stages from embryogenesis to adulthood. We identified 1,808,810 genomic regions that showed variations...
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