Article

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

2021-04-27

Abstract excerpt

Microscale changes in tissue environment are translated to changes in cell behavior and phenotype, yet the mechanisms behind how these phenotypic changes occur are poorly understood. Here, we describe and model chromatin, which stores genetic information within the cell nucleus, as a dynamic nanomaterial whose configuration is modulated by chemo-mechanical cues in the microenvironment. Our findings indicate that p...

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Literature Corpus work: e6d3a1b9-05e3-582b-92fd-9337a5a4bfae
DOI: 10.1101/2021.04.27.441596

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