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Article

Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential.

Biophysical journal - 18 Apr 2023

Scott Adrienne K, Casas Eduard, Schneider Stephanie E, Swearingen Alison R, Van Den Elzen Courtney L, Seelbinder Benjamin, Barthold Jeanne E, Kugel Jennifer F, Stern Josh Lewis, Foster Kyla J, Emery Nancy C, Brumbaugh Justin, Neu Corey P

Abstract excerpt

Understanding how cells remember previous mechanical environments to influence their fate, or mechanical memory, informs the design of biomaterials and therapies in medicine. Current regeneration therapies, such as cartilage regeneration procedures, require 2D cell expansion processes to achieve large cell populations critical for the repair of damaged tissues. However, the limit of mechanical priming for...

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Share to Cartilage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chondrocytes

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Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 36871159
DOI: 10.1016/j.bpj.2023.03.004
PMCID: PMC10147835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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