Article

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness

2024-01-10

Abstract excerpt

Epigenetic control of cellular transcription and phenotype is influenced by changes in the cellular microenvironment, yet how mechanical cues from these microenvironments precisely influence epigenetic state to regulate transcription remains largely unmapped. Here, we combine genome-wide epigenome profiling, epigenome editing, and phenotypic and single-cell RNA-seq CRISPR screening to identify a new class of genom...

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Literature Corpus work: f0a476ee-fdc7-592f-939c-ea567abaaf3a
DOI: 10.1101/2024.01.10.574997

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