Article
The 3D nuclear position and compartmentalization of genes prime their response to mechano-confinement
2025-11-07
Abstract excerpt
Cells continuously receive mechanical inputs from their environment. For example, during migration in narrow spaces, or in solid tumors, cells and their nuclei experience confinement which they sense and respond to. Emerging evidence identifies the genome as a central mediator of these responses, dynamically reorganizing its three-dimensional (3D) structure to regulate both short- and long-term gene expression pro...
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Identifiers and source
- Literature Corpus work
- ff7092ed-8a7f-5a96-849f-75271d5aa0a1
- DOI
- 10.1101/2025.11.06.686901