Article

Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids

2023-11-15

Abstract excerpt

<title>Abstract</title> <p><italic><bold>Background: </bold></italic>Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper-physiological mechanical cues are known to play a critical role in the onset and prog...

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Literature Corpus work: e6352e62-ae02-564f-b40e-35932d46bb6c
DOI: 10.21203/rs.3.rs-3568544/v1

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