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Article

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells

17 Aug 2018

Abstract excerpt

Variations in a multitude of material microenvironmental properties have been observed across tissues in vivo, and these have profound effects on cell phenotype. Phenomenological experiments have suggested that certain of these features of the physical microenvironment, such as stiffness, could sensitize cells to other features; meanwhile, mechanistic studies have detailed a number of biophysical mechanisms for...

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PMID: 30120125
DOI: 10.1073/pnas.1802568115

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