Article

The stiffness-sensitive transcriptome of human tendon stromal cells

2021-05-27

Abstract excerpt

Matrix stiffness and its effects on tensional homeostasis act as major regulators of cellular states in health and disease. Stiffness-sensing studies are typically performed using cells that have acquired “mechanical memory” through prolonged propagation in rigid mechanical environments, e.g. tissue culture plastic (TCP). This may potentially mask the full extent of the stiffness-driven mechanosensing programs. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d353d76-3232-53b0-b560-e4eb67b0a49b
DOI: 10.1101/2021.05.27.445865

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The stiffness-sensitive transcriptome of human tendon stromal cellsDOI 10.1101/2021.05.27.445865Read

The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal CellsSemantic proximity Read

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read

Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair.Semantic proximity Read

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cellsSemantic proximity Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathySemantic proximity Read

Human tendon-on-a-chip for modeling vascular inflammatory fibrosisSemantic proximity Read

Sustained mechanical tension governs fibrogenic activation of tendon stromal cells in systemic sclerosisSemantic proximity Read

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions.Semantic proximity Read

Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendonSemantic proximity Read

Single-cell transcriptomic profiling reveals distinct mechanical responses between normal and diseased tendon progenitor cellsSemantic proximity Read

Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendonsSemantic proximity Read