Article

Hydrogel mechanics regulate fibroblast DNA methylation and chromatin condensation

2022-12-14

Abstract excerpt

Cellular mechanotransduction plays a central role in fibroblast activation during fibrotic disease progression, leading to increased tissue stiffness and reduced organ function. While the role of epigenetics in disease mechanotransduction has begun to be appreciated, there is little known about how substrate mechanics, particularly the timing of mechanical inputs, regulate epigenetic changes such as DNA methylatio...

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Literature Corpus work: 3cf0e4ef-0f14-59b2-bab5-9035096ba98a
DOI: 10.1101/2022.12.13.520341

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