Article

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

2024-06-25

Abstract excerpt

The interactions between chromatin and the nuclear lamina orchestrate cell type-specific gene activity by forming lamina-associated domains (LADs) which preserve cellular characteristics through gene repression. However, unlike the interactions between chromatin segments, the strength of chromatin-lamina interactions and their dependence on cellular environment are not well understood. Here, we develop a theory to...

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Identifiers and source

Literature Corpus work: b4d9d281-f7de-517d-99df-08192dfe7d68
DOI: 10.1101/2024.06.24.600310

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