Article

Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblasts

2026-05-31

Abstract excerpt

Periodontal disease is characterized by progressive degradation of the gingival extracellular matrix and loss of the physical confinement it imposes on resident stromal cells. In human periodontal tissue, ECM collagen integrity is inversely correlated with facultative nuclear histone acetylation in stromal cells. We hypothesized that matrix stiffness directly coordinates an epigenomic shift in stromal cells. We us...

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Literature Corpus work: 58d08eb7-45e7-5d72-9cab-52252f60bf12
DOI: 10.64898/2026.05.27.728299

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