Article

Chromatin organization controls nuclear stiffness

2025-03-15

Abstract excerpt

Cellular differentiation is driven by epigenetic modifiers and readers, including the methyl CpG binding protein 2 (MeCP2), whose level and mutations cause the neurological disorder Rett syndrome. During differentiation, most of the genome gets densely packed into heterochromatin, whose function has been simplistically viewed as gene silencing. However, gene expression changes reported in mutations leading to Rett...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 675bfb5e-14fa-5383-be19-8898a3ddeabb
DOI: 10.1101/2025.03.14.643219

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin organization controls nuclear stiffnessDOI 10.1101/2025.03.14.643219Read

MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.Semantic proximity Read

Differential dynamics specify MeCP2 function at methylated DNA and nucleosomesSemantic proximity Read

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue CellsSemantic proximity Read

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesisSemantic proximity Read

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formationSemantic proximity Read

Chromatin histone modifications and rigidity affect nuclear morphology independent of laminsSemantic proximity Read

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution ImagingSemantic proximity Read

Extracellular matrix stiffness regulates fibroblast differentiation by influencing DNA methyltransferase 1 expression through microtubule polymerizationSemantic proximity Read

Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.Semantic proximity Read

Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblastsSemantic proximity Read

Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research.Semantic proximity Read

The 3D nuclear position and compartmentalization of genes prime their response to mechano-confinementSemantic proximity Read