Article

Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation

2021-02-04

Abstract excerpt

<title>Abstract</title> <p>Efficient manipulation of cell fate is important for regenerative engineering applications. Lineage-specific differentiation of stem cells is particularly challenging due to their inherent plasticity. Engineered topographies may alter cellular plasticity through contact guidance. However, the ability to rationally design topographies to regulate phenotypic outcomes has been hindered in...

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Literature Corpus work: 6ebe62ea-6740-5c9c-83a9-290bdd3a9366
DOI: 10.21203/rs.3.rs-155599/v1

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