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Article

Architectural control of mesenchymal stem cell phenotype through nuclear actin.

Nucleus (Austin, Tex.) - 1 Dec 2022

Rubin Janet, van Wijnen Andre J, Uzer Gunes

Abstract excerpt

There is growing appreciation that architectural components of the nucleus regulate gene accessibility by altering chromatin organization. While nuclear membrane connector proteins link the mechanosensitive actin cytoskeleton to the nucleoskeleton, actin's contribution to the inner architecture of the nucleus remains enigmatic. Control of actin transport into the nucleus, plus the presence of proteins that...

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Identifiers

PMID: 35133922
DOI: 10.1080/19491034.2022.2029297
PMCID: PMC8837231

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