Article

A systematic survey of distal element-gene regulatory interactions with Direct-Capture Targeted Perturb-seq

2025-09-17

Abstract excerpt

Identifying the impact of distal regulatory elements on gene expression is a core challenge in human genetics. Large-scale CRISPR screens have not captured lower effect size element-gene interactions due to selection bias and limited statistical power. We developed a framework for highly powered CRISPR screens, consisting of Direct-Capture Targeted Perturb-seq (DC-TAP-seq), unbiased target selection, and a pipelin...

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Literature Corpus work: e6beb173-8d61-5c57-8e65-cb31ff0827d3
DOI: 10.1101/2025.09.16.676677

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