Article

Mammalian enhancers and GWASs act proximally and seldom skip active genes

2024-12-03

Abstract excerpt

<h4>Summary</h4> Enhancers play a critical role in regulating transcription. Nearly 90% of human genetic variants identified in genome-wide association studies (GWAS) are located in distal regions, underscoring the importance of enhancers in human development, diseases, and traits. It is widely suggested that mammalian enhancers frequently skip active genes, and thus, linear proximity is a poor predictor of their...

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Literature Corpus work: 39b7e3d2-286d-5c1e-afba-f01950e5f09a
DOI: 10.1101/2024.11.29.625864

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