Article

Genome-wide annotation of gene regulatory elements linked to cell fitness

2021-03-09

Abstract excerpt

Noncoding regulatory elements control gene expression and thus govern nearly all biological processes. Epigenomic profiling assays have identified millions of putative regulatory elements, but systematically determining the function of those regulatory elements remains a substantial challenge. Here we adapt CRISPR screening by epigenetic repression to screen all 111,619 putative non-coding regulatory elements defi...

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Literature Corpus work: 3dbf0d9d-b346-59a4-a4d1-7d611d912131
DOI: 10.1101/2021.03.08.434470

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