Article

Massively parallel reporter assay–informed modeling improves prediction of context-specific enhancer–gene regulatory interactions

2026-05-05

Abstract excerpt

Enhancers are cis-regulatory elements that drive context-specific gene expression, yet their target genes and modes of action remain largely unresolved. Because most disease-associated variants lie in non-coding regulatory DNA, accurate, cell type–specific enhancer–gene (E–G) mapping is essential for understanding genetic risk. However, current E–G prediction frameworks lack the resolution to capture such context-...

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Literature Corpus work: 72d97b06-2e42-53e2-a84c-49a6256b91e5
DOI: 10.64898/2026.05.01.722242

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