Article

Enhancer-gene regulatory interactions in colorectal cancer revealed through genome-wide CRISPRi perturbations

2026-06-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Establishing functional relationships between distal enhancers and their target genes is a central challenge in genome biology and cancer genetics. CRISPR/dCas9-mediated perturbations followed by single-cell RNA sequencing (Perturb-seq) has emerged as an efficient means of establishing enhancer-target gene relationships. <h4>Results</h4> We used genome-wide CRISPRi Perturb-...

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Literature Corpus work: e650e510-74b8-5dcb-bb5b-78c1f7566d4e
DOI: 10.64898/2026.06.05.730086

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