Article

Single-molecule Imaging of SWI/SNF Chromatin Remodelers Reveal Multi-modal and Cancer-mutant-specific Landscape of DNA-binding Dynamics

2023-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin remodeling, carried out by multi-subunit remodeler complexes, alleviates topological constraints posed by nucleosomes to regulate genome access. Although mutations in the SWI/SNF subfamily of remodelers are implicated in >20% of human cancers, how misregulation of their intranuclear dynamics could underpin cancer remains poorly understood. Combining single-molecule tracking and fluores...

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Literature Corpus work: e628aa78-bb3a-56fd-98ed-2dcc990632e0
DOI: 10.1101/2023.07.28.550968

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