Article
Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2016
Pulice John L, Kadoch Cigall
Abstract excerpt
Mammalian SWI/SNF (BAF) chromatin remodeling complexes play critical roles in maintaining chromatin architecture and gene expression. Genomic sequencing efforts over the past several years have unveiled a major role for these complexes in the development of human cancer as well as neurologic disease, prompting the need to interrogate underlying mechanisms and to develop new methods to comprehensively understand...
Topics
- Animals
- Cell Nucleus
- Chromatin
- Chromatin Assembly and Disassembly
- DNA-Binding Proteins
- Genetic Predisposition to Disease
- Humans
- Transcription Factors