Structure of nucleosome-bound human BAF complex.

doi:10.1126/science.aaz9761

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Article

Structure of nucleosome-bound human BAF complex.

Science (New York, N.Y.) - 21 Feb 2020

He Shuang, Wu Zihan, Tian Yuan, Yu Zishuo, Yu Jiali, Wang Xinxin, Li Jie, Liu Bijun, Xu Yanhui

Abstract excerpt

Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their mutations are linked to cancers. The 3.7-angstrom-resolution cryo-electron microscopy structure of human BAF bound to the...

Topics

Adenosine Triphosphatases
Adenosine Triphosphate
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
Cryoelectron Microscopy
DNA Helicases
DNA-Binding Proteins
Humans
Hydrolysis
Mutation
Neoplasms
Nuclear Proteins
Nucleosomes
Protein Conformation, alpha-Helical
SMARCB1 Protein
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 32001526
DOI: 10.1126/science.aaz9761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-32001526-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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