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Global identification of direct SWI/SNF targets reveals compensation by EP400

2023-03-07

Abstract excerpt

<h4>Summary</h4> Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are commonly mutated in disease, therapeutic options are limited by our inability to predict SWI/SNF gene targets and conflicting studies on functional significance. Here, we leverage a fast-acting inhibitor of SWI/SNF remodeling to elucidat...

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Literature Corpus work
52d120c1-1997-5e5b-9082-c6f10c89f41f
DOI
10.1101/2023.03.07.531379
Open publication

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Global identification of direct SWI/SNF targets reveals compensation by EP400DOI 10.1101/2023.03.07.531379
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