Article
The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Aug 2020
Sanchez Julio C, Zhang Liyang, Evoli Stefania, Schnicker Nicholas J, Nunez-Hernandez Maria, Yu Liping, Wereszczynski Jeff, Pufall Miles A, Musselman Catherine A
Abstract excerpt
The ATP-dependent BAF chromatin remodeling complex plays a critical role in gene regulation by modulating chromatin architecture, and is frequently mutated in cancer. Indeed, subunits of the BAF complex are found to be mutated in >20% of human tumors. The mechanism by which BAF properly navigates chromatin is not fully understood, but is thought to involve a multivalent network of histone and DNA contacts. We...
Topics
- Base Pairing
- Chromatin
- Chromatin Assembly and Disassembly
- DNA
- DNA Helicases
- Gene Expression Regulation
- Histones
- Humans
- Molecular Dynamics Simulation
- Mutation