Article

The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain

2019-11-25

Abstract excerpt

The ATP-dependent BAF chromatin remodeling complex plays a critical role in gene regulation by modulating chromatin architecture, and is frequently mutated in cancer. Indeed, subunits of the BAF complex are found to be mutated in >20% of human tumors. The mechanism by which BAF properly navigates chromatin is not fully understood, but is thought to involve a multivalent network of histone and DNA contacts. We prev...

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Literature Corpus work: 025b6998-48ad-52ed-bfee-a9df8498ece7
DOI: 10.1101/854000

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