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Article

BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains.

Cells - 9 Jan 2026

Seitz Clayton, Fu Donghong, Liu Mengyuan, Ma Hailan, Liu Jing

Abstract excerpt

The interplay between chromatin structure and phase-separating proteins is an emerging topic in cell biology with implications for understanding disease states. Here, we investigate the functional relationship between bromodomain protein 4 (BRD4) and chromatin architecture. By combining molecular dynamics simulations with live-cell imaging, we demonstrate that BRD4, when mutated at specific N-terminus sites,...

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Identifiers

PMID: 41597193
DOI: 10.3390/cells15020118
PMCID: PMC12838699

Genes

BRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains.PMID 41597193Read ↗

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