The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin.

doi:10.1016/j.molcel.2025.03.026

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Article

The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin.

Molecular cell - 1 May 2025

Grossi Elena, Nguyen Christie B, Carcamo Saul, Kirigin Callaú Valentina, Moran Shannon, Filipescu Dan, Tagore Somnath, Firestone Tessa M, Keogh Michael-Christopher, Sun Lu, Izar Benjamin, Hasson Dan, Bernstein Emily

Abstract excerpt

SWI/SNF (switch/sucrose non-fermentable) chromatin remodelers possess unique functionalities difficult to dissect. Distinct cancers harbor mutations in specific subunits, such as the polybromo-associated BAF (PBAF)-specific component ARID2 in melanoma. Here, we perform epigenomic profiling of SWI/SNF complexes and their associated chromatin states in melanocytes and melanoma. Time-resolved approaches reveal that...

Topics

Humans
Transcription Factors
Melanoma
Chromatin
Chromatin Assembly and Disassembly
Repressor Proteins
Melanocytes
Gene Expression Regulation, Neoplastic
Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Cell Line, Tumor

DNA-Binding Proteins

Brain Neoplasms

Animals

RE1-Silencing Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 40252649
DOI: 10.1016/j.molcel.2025.03.026
PMCID: PMC12048221

Genes

ARID2
REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-40252649-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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