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Article

Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain.

Journal of molecular biology - 9 Jul 2021

Lupo Brianna E, Chu Peirou, Harms Michael J, Morrison Emma A, Musselman Catherine A

Abstract excerpt

The BAF chromatin remodeling complex is critical for genome regulation. The central ATPase of BAF is either BRM or BRG1, both of which contain a C-terminal bromodomain, known to associate with acetylated lysines. We have recently demonstrated that in addition to acetyl-lysine binding, the BRG1/BRM bromodomain can associate with DNA through a lysine/arginine rich patch that is adjacent to the acetyl-lysine binding...

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Identifiers

PMID: 33539881
DOI: 10.1016/j.jmb.2021.166845
PMCID: PMC8184587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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