Article

Downward bias in the association between APOE and Alzheimer’s Disease using prevalent and by-proxy disease sampling in the All of Us Research Program

2025-05-23

Abstract excerpt

<h4>Background</h4> Recent genome-wide association studies (GWAS) for Alzheimer’s Disease and related dementias (ADRD) have increased statistical power via larger analysis datasets from biobanks by 1) including non-age-matched controls and prevalent cases, and/or 2) including individuals who report a family history of ADRD as proxy cases. However, these methods have the potential to increase noise and distort gene...

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Literature Corpus work: e4fd9cb6-accc-5a0e-a50a-aa6404d7fa9a
DOI: 10.1101/2025.05.22.25328175

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