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Article

Pervasive biases in proxy genome-wide association studies based on parental history of Alzheimer's disease.

Nature genetics - 1 Dec 2024

Wu Yuchang, Sun Zhongxuan, Zheng Qinwen, Miao Jiacheng, Dorn Stephen, Mukherjee Shubhabrata, Fletcher Jason M, Lu Qiongshi

Abstract excerpt

Almost every recent Alzheimer's disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history. Here, we report major limitations in current GWAS-by-proxy (GWAX) practices due to uncorrected survival bias and nonrandom participation in parental illness surveys, which cause...

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PMID: 39496879
DOI: 10.1038/s41588-024-01963-9

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