Article

Pervasive biases in proxy GWAS based on parental history of Alzheimer’s disease

2023-10-17

Abstract excerpt

Almost every recent Alzheimer’s disease (AD) genome-wide association study (GWAS) has performed meta-analysis to combine studies with clinical diagnosis of AD with studies that use proxy phenotypes based on parental disease history. Here, we report major limitations in current GWAS-by-proxy (GWAX) practices due to uncorrected survival bias and non-random participation of parental illness survey, which cause substa...

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Literature Corpus work: 841177e0-4aa0-5730-b4aa-e44eabef73a1
DOI: 10.1101/2023.10.13.562272

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