Article

The proportion of Alzheimer’s disease attributable to apolipoprotein E

2023-11-17

Abstract excerpt

Variation in the APOE gene strongly affects Alzheimer’s disease (AD) risk. However, the proportion of AD burden attributable to this variation requires clarification. We estimated the extents to which clinically diagnosed AD, AD neuropathology and all-cause dementia are attributable to the common APOE alleles in four large studies. First, we used data on 171,105 and 289,150 participants aged ≥60 years from UK Biob...

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Literature Corpus work: 54bce0d7-3d88-5199-9bd9-54a0e782ebbe
DOI: 10.1101/2023.11.16.23298475

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