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Article

Impact of APOE4-related dementia risk in underrepresented groups from the All of Us research program.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2025

Ghisays Valentina, Khajouei Ehsan, Piras Ignazio S, Malek-Ahmadi Michael H, Protas Hillary D, Goradia Dhruman D, Chen Yinghua, Naymik Marcus, Saner Donald, Veatch Olivia J, Mansel Clayton O, Su Yi, Huentelman Matthew J, Karnes Jason H, Reiman Eric M

Abstract excerpt

INTRODUCTION: Longitudinal electronic health records (EHRs), "dementia" diagnostic codes, and genetic data from All of Us were used to see if there is a higher risk of dementia and an attenuated impact of apolipoprotein ε4 (APOE4) on Alzheimer's disease (AD) risk in Black and Hispanic/Latino groups. METHODS: Participants included 9,784 Hispanic/Latinos, 14,937 Non-Hispanic Blacks (NHB), and 60,388 Non-Hispanic...

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Identifiers

PMID: 40501118
DOI: 10.1002/alz.70245
PMCID: PMC12159303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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