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Article

Phenome-wide association of APOE alleles in the All of Us Research Program

30 May 2025

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) variation is associated with altered lipid metabolism, as well as cardiovascular and neurodegenerative disease. Prior studies are largely limited to European ancestry populations and differential risk by sex and ancestry has not been widely evaluated. METHODS: We utilised a phenome-wide association study (PheWAS) to explore APOE-associated phenotypes in the All of Us Research...

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PMID: 40451134
DOI: 10.1016/j.ebiom.2025.105768

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