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Article

Downward bias in the association between APOE and Alzheimer's disease using prevalent and by-proxy disease sampling in the All of Us research program.

BMC medical genomics - 11 Apr 2026

Mansel Clayton O, Ghisays Valentina, Mahnken Jonathan D, Swerdlow Russell H, Reiman Eric M, Karnes Jason H, Denny Joshua C, Veatch Olivia J

Abstract excerpt

BACKGROUND: Recent genome-wide association studies for Alzheimer’s Disease and related dementias (ADRD) have increased statistical power via larger analysis datasets from biobanks by (1) including non-age-matched controls and prevalent cases, and/or (2) including individuals who report a family history of ADRD as proxy cases. However, these methods have the potential to increase noise and distort genetic...

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Identifiers

PMID: 41965633
DOI: 10.1186/s12920-026-02362-1
PMCID: PMC13191872

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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