Article

Greater Effect of Polygenic Risk Score for Alzheimer’s Disease Among Younger Cases who are Apolipoprotein E-ε4 Carriers

2020-04-08

Abstract excerpt

To evaluate how age and Apolipoprotein E-ε4 ( APOE4) status interact with APOE- independent polygenic risk score (PRS non-APOE ), we estimated PRS non-APOE in superagers (age ≥ 90 years, N=346), 89- controls (age 60-89, N=2,930) and Alzheimer’s Disease (AD) cases (N=1,760). Employing superagers, we see a nearly five times greater odds ratio (OR) for AD comparing the top PRS non-APOE decile to the lowest decile (OR...

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Literature Corpus work: d6c1cb4c-bc89-5624-a6c8-7a83bf07dd7c
DOI: 10.1101/2020.04.06.20052332

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