Article

Multivariate Modeling of Direct and Proxy GWAS Indicates Substantial Common Variant Heritability of Alzheimer’s Disease

2021-05-10

Abstract excerpt

Genome-wide association studies (GWAS) of proxy-phenotypes using family history of disease (GWAX) substantially boost power for genetic discovery when combined with direct case-control GWAS, most prominently in the context of Alzheimer’s Disease (AD). However, despite twin study heritability estimates of approximately 60%, recent SNP-based estimates of common variant heritability of AD from meta-analyzed GWAS-GWAX...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4eff5ea0-b656-5a8b-a85b-1aaad6a2b235
DOI: 10.1101/2021.05.06.21256747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multivariate Modeling of Direct and Proxy GWAS Indicates Substantial Common Variant Heritability of Alzheimer’s DiseaseDOI 10.1101/2021.05.06.21256747Read

Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region.Semantic proximity Read

Genomic analyses reveal new insights into Alzheimer's diseaseSemantic proximity Read

Interpretation of 10 years of Alzheimer's disease genetic findings in the perspective of statistical heterogeneity.Semantic proximity Read

Pervasive biases in proxy GWAS based on parental history of Alzheimer’s diseaseSemantic proximity Read

Beyond guilty by association at scale: searching for causal variants on the basis of genome-wide summary statisticsSemantic proximity Read

Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypesSemantic proximity Read

Pervasive biases in proxy genome-wide association studies based on parental history of Alzheimer's disease.Semantic proximity Read

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.Semantic proximity Read

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populationsSemantic proximity Read

Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer's disease GWAS and self-report proxy phenotype GWAX.Semantic proximity Read

Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's diseaseSemantic proximity Read

Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort.Semantic proximity Read