Article

A Favorable Modifiable Risk Factor Profile Mitigates Polygenic Risk for Alzheimer’s Disease and Related Dementia

2026-06-02

Abstract excerpt

<h4>Background</h4> A recent Lancet Commission estimated that up to 45% of Alzheimer’s Disease and Related Dementias (ADRD) cases could be prevented by addressing modifiable lifestyle risk factors. Meanwhile, genome-wide association studies (GWAS) have shown that common genetic variants also account for substantial ADRD risk. Whether a favorable lifestyle can offset risk in genetically predisposed individuals rem...

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Literature Corpus work: 897ea8d6-98f7-55d7-99e4-26e61e4f7840
DOI: 10.64898/2026.06.01.26354634

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