Article
Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region.
PLoS genetics - 1 Jun 2022
de la Fuente Javier, Grotzinger Andrew D, Marioni Riccardo E, Nivard Michel G, Tucker-Drob Elliot M
Abstract excerpt
Recent meta-analyses combining direct genome-wide association studies (GWAS) with those of family history (GWAX) have indicated very low SNP heritability of Alzheimer's disease (AD). These low estimates may call into question the prospects of continued progress in genetic discovery for AD within the spectrum of common variants. We highlight dramatic downward biases in previous methods, and we validate a novel...
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