Article

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic Arthritis

2024-02-17

Abstract excerpt

Juvenile Idiopathic Arthritis (JIA) describes a heterogeneous group of autoimmune conditions with an unknown cause and childhood onset. It is characterized by the accumulation of mononuclear cells, notably activated CD4+ memory/effector T (Tmem/Teff) cells, within the synovial fluid of affected joints. JIA CD4+ T cells exhibit a unique epigenomic signature linked to inflammation, however, the molecular mechanisms...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e45cb3ce-54bf-55a4-bcaf-38332e4afd22
DOI: 10.1101/2024.02.14.580242

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic ArthritisDOI 10.1101/2024.02.14.580242Read

Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritisSemantic proximity Read

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cellsSemantic proximity Read

Epigenetic and Metabolic Reprogramming in Autoimmune Rheumatology: Toward Next-Generation Immune RegulationSemantic proximity Read

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolismSemantic proximity Read

A Glycolysis-Fatty Acid Metabolic Axis Shapes Human Tfh Cell FunctionSemantic proximity Read

Integrative multi-omics analyses identify PKD1 and SLC2A4 as genetically supported glycolysis-related candidate genes for rheumatoid arthritis.Semantic proximity Read

Metabolic Reprogramming of Pathogenic CD4 <sup>+</sup> T Helper Cells Attenuates Inflammatory Bowel Disease PathogenesisSemantic proximity Read

Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation <i>via</i> MG-derived AGE–RAGE signalingSemantic proximity Read

Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA SequencingSemantic proximity Read

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4 <sup>+</sup> T Cell Effector FunctionSemantic proximity Read

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancySemantic proximity Read

Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector functionSemantic proximity Read