Article

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

2017-11-13

Abstract excerpt

<h4>Summary</h4> It is well known that some pathogenic cells have enhanced glycolysis, the regulatory network leading to increased glycolysis are not well characterized. Here, we show that pathogenic T H 17 cells specifically upregulate glycolytic pathway genes compared to homeostatic T H 17 cells. Bioenergetic assay and metabolomics analyses indicate that pathogenic T H 17 cells are highly glycolytic compared...

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Literature Corpus work: a3a0522c-eb59-5a0d-85f7-e2e2b2d007fb
DOI: 10.1101/218545

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