Article

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

2019-11-29

Abstract excerpt

<h4> <h4>Summary: </h4> </h4> Targeting glycolysis has been considered therapeutically intractable owing to its essential housekeeping role. However, the context-dependent requirement for individual glycolytic steps has not been fully explored. We show that CRISPR-mediated targeting of glycolysis in T cells in mice results in global loss of Th17 cells, whereas deficiency of the glycolytic enzyme glucose phosphat...

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Literature Corpus work: c43d0196-730e-5563-8d88-677eaf23116a
DOI: 10.1101/857961

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