Article

Epigenetic and Metabolic Reprogramming in Autoimmune Rheumatology: Toward Next-Generation Immune Regulation

2025-12-30

Abstract excerpt

Autoimmune rheumatic diseases arise when the immune system transitions from a flexible, self-regulating network into a metabolically and epigenetically fixed inflammatory attractor state. This review synthesizes emerging evidence that immune tolerance is governed by a coupled epigenetic–metabolic axis integrating mitochondrial fitness, chromatin accessibility, redox balance, and nutrient flux across lymphoid, myel...

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Literature Corpus work: 34cf098a-f2ac-573e-bf5f-54e38a7daafd
DOI: 10.20944/preprints202512.2693.v1

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