Article

Metabolic Reprogramming of Pathogenic CD4 <sup>+</sup> T Helper Cells Attenuates Inflammatory Bowel Disease Pathogenesis

2025-04-20

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> CD4 + T helper 1 (Th1) cells are involved in human inflammatory bowel disease (IBD) pathogenesis; however, mechanisms governing the persistent inflammatory function of these cells are unclear, leading us to examine how metabolism governs Th1 cell-induced IBD. <h4>METHODS</h4> Th1 cells supplemented with methyl pyruvate (MePyr) were analyzed to define how enforced mitochondrial pyruva...

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Literature Corpus work: b82a9709-d8b2-54d2-9554-62c3bb6aa874
DOI: 10.1101/2025.04.15.649047

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