Article

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

2019-10-30

Abstract excerpt

T helper (Th) cells are CD4+ effector T cells that play an instrumental role in immunity by shaping the inflammatory cytokine environment in a variety of physiological and pathological situations. Using a combined chemico-genetic approach we identify histone H3K27 demethylases KDM6A and KDM6B as central regulators of human Th subsets. The prototypic KDM6 inhibitor GSK-J4 increases genome-wide levels of the repress...

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Literature Corpus work: 385905e9-5c9f-53cb-9640-018823975e3a
DOI: 10.1101/820845

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