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Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritis

1 Feb 2025

Abstract excerpt

Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by accumulation of activated CD4 + T cells in the synovial fluid (SF) of affected joints. JIA CD4 + T cells exhibit a unique inflammation-associated epigenomic signature, but the underlying mechanisms remain unclear. We demonstrate that CD4 + T cells from JIA SF display heightened glycolysis upon activation and JIA-specific H3K27...

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PMID: 40009514
DOI: 10.1016/j.celrep.2025.115287

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