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Article

Integrative multi-omics analyses identify PKD1 and SLC2A4 as genetically supported glycolysis-related candidate genes for rheumatoid arthritis.

Frontiers in immunology - 1 Jan 2025

A Xinyu, Xin Pengfei, Zheng Lin, Xu Bo, Wang Jianye, Sun Songtao, Xie Jun, Gao Chenxin, Pan Peijun, Qiu Guowei, Jin Lang, Shen Jun, Xu Xirui, Cheng Yiwei, Pei Shaoqiang, Ran Lei, Bian Yanqin, Xiao Lianbo

Abstract excerpt

Introduction: Glycolytic reprogramming has been implicated in rheumatoid arthritis (RA) pathogenesis, yet the underlying causal genes and epigenetic mechanisms remain unclear. This study aimed to systematically identify glycolysis-related genes and their methylation-regulated expression that may causally influence RA susceptibility. Methods: We conducted a multi-omics Mendelian randomization (MR) analysis...

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Share to Arthritis, Rheumatoid
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Glycolysis

Share to Mendelian Randomization Analysis

Share to Multiomics

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Source

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Identifiers

PMID: 41693713
DOI: 10.3389/fimmu.2025.1691663
PMCID: PMC12895683

Genes

PKD1
SLC2A4
ALAS1
PFKFB2
ALDH7A1
PYGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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