Article

Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>Janus kinase inhibitors (JAKis) are widely prescribed for autoimmune diseases, but their use is associated with increased infection risk. The mechanisms underlying this susceptibility remain unclear. CD8 T cells play a central role in antimicrobial defense, yet little is known about how JAKis reprogram their activation and effector programs. Here, we investigated naïve and memory CD8 T...

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Literature Corpus work: 8dcaaca1-5a62-5661-8b09-5c54e2c5b09a
DOI: 10.21203/rs.3.rs-7794494/v1

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