Article

Integrative Multi-Omics Identifies CDK1 as a Key Signaling Regulator of CD4 <sup>+</sup> T Cell Effector Function

2025-10-31

Abstract excerpt

CD4⁺ T cell differentiation is orchestrated by coordinated signaling, transcriptional, and epigenomic programs, yet how signaling connects to chromatin and genetic variation in human T cells remains unclear. Here, we generated an integrative multi-omics map of human CD4⁺ T cell activation and differentiation, combining phosphoproteomics, transcriptomics, and chromatin accessibility under Th0, Th1, and iTreg polari...

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Literature Corpus work: 085e5c73-e7af-517a-a54f-f87b9b6516fe
DOI: 10.1101/2025.10.30.685551

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